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FLNA a ubiquitous cytoskeletal protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Plays an essential role in embryonic cell migration. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interactions with filamin A may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: actin cytoskeleton; cell soma; cortical cytoskeleton; cytoplasm; cytosol; dendritic shaft; extracellular exosome; extracellular matrix; extracellular region; filamentous actin; focal adhesion; intercellular junction; membrane; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; Z disc
Molecular Function: actin filament binding; cadherin binding; G-protein coupled receptor binding; GTPase binding; ion channel binding; kinase binding; mu-type opioid receptor binding; potassium channel regulator activity; protein binding; protein homodimerization activity; Rac GTPase binding; Ral GTPase binding; Rho GTPase binding; RNA binding; signal transducer activity; SMAD binding; small GTPase binding; transcription factor binding
Biological Process: actin crosslink formation; actin cytoskeleton reorganization; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cerebral cortex development; cytoplasmic sequestering of protein; establishment of protein localization; formation of radial glial scaffolds; mitotic spindle assembly; mRNA transcription from RNA polymerase II promoter; negative regulation of apoptosis; negative regulation of protein catabolic process; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase I promoter; platelet activation; platelet degranulation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of integrin-mediated signaling pathway; positive regulation of neural precursor cell proliferation; positive regulation of neuron migration; positive regulation of potassium ion transmembrane transport; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of transcription factor import into nucleus; protein localization to cell surface; protein localization to plasma membrane; protein stabilization; receptor clustering; regulation of cell migration; regulation of membrane repolarization during atrial cardiac muscle cell action potential; regulation of membrane repolarization during cardiac muscle cell action potential; semaphorin-plexin signaling pathway; wound healing, spreading of cells
Disease: Cardiac Valvular Dysplasia, X-linked; Fg Syndrome 2; Frontometaphyseal Dysplasia; Heterotopia, Periventricular, Ehlers-danlos Variant; Heterotopia, Periventricular, X-linked Dominant; Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-linked; Melnick-needles Syndrome; Otopalatodigital Syndrome, Type I; Otopalatodigital Syndrome, Type Ii; Terminal Osseous Dysplasia
Reference #:  P21333 (UniProtKB)
Alt. Names/Synonyms: ABP-280; ABPX; actin binding protein 280; Actin-binding protein 280; Alpha-filamin; DKFZp434P031; Endothelial actin-binding protein; filamin 1; filamin A, alpha; Filamin-1; Filamin-A; FLN; FLN-A; FLN1; FLNA; FMD; MNS; NHBP; Non-muscle filamin; OPD; OPD1; OPD2
Gene Symbols: FLNA
Molecular weight: 280,739 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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