Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

BAFF Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell cycle regulation; Cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q33.3
Cellular Component: cytoplasm; extracellular region; extracellular space; integral component of membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function: cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding
Biological Process: B cell costimulation; B cell homeostasis; cell proliferation; immune response; immunoglobulin secretion; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of germinal center formation; positive regulation of T cell proliferation; signal transduction; T cell costimulation; tumor necrosis factor-mediated signaling pathway
Reference #:  Q9Y275 (UniProtKB)
Alt. Names/Synonyms: ApoL related ligand TALL-1; B lymphocyte stimulator; B-cell activating factor; B-cell-activating factor; B-lymphocyte stimulator; BAFF; BLYS; CD257; delta BAFF; Dendritic cell-derived TNF-like molecule; DTL; TALL-1; TALL1; THANK; TN13B; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; TNF- and APOL-related leukocyte expressed ligand 1; TNFSF13B; TNFSF20; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor (ligand) superfamily, member 20; Tumor necrosis factor ligand superfamily member 13B; Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form; tumor necrosis factor superfamily, member 13b; tumor necrosis factor-like protein ZTNF4; ZTNF4
Gene Symbols: TNFSF13B
Molecular weight: 31,223 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene