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MST4 a S/T protein kinase of the STE20 family. Mst kinases regulate processes such as apoptosis, morphogenesis, and cytoskeletal rearrangements, and are upstream activators of MAPK pathways that. The amino-terminal kinase domain of Mst is considerably homologous to the kinase domain of yeast STE20 kinase and other p21-activated kinases. otential mediator of cell growth. Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; YSK subfamily
Chromosomal Location of Human Ortholog: Xq26.2
Cellular Component: apical plasma membrane; cytoplasm; cytosol; Golgi apparatus; Golgi-associated vesicle; membrane; perinuclear region of cytoplasm; vesicle membrane
Molecular Function: ATP binding; identical protein binding; magnesium ion binding; MAP kinase kinase kinase kinase activity; protein binding; protein homodimerization activity; protein kinase activity
Biological Process: cellular response to starvation; microvillus biogenesis; negative regulation of cell migration; neurite morphogenesis; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; response to hydrogen peroxide; stress-activated protein kinase signaling pathway
Reference #:  Q9P289 (UniProtKB)
Alt. Names/Synonyms: Mammalian STE20-like protein kinase 4; mammalian sterile 20-like 4; MASK; MST-4; Mst3 and SOK1-related kinase; MST4; serine/threonine protein kinase MASK; serine/threonine protein kinase MST4; Serine/threonine-protein kinase 26; Serine/threonine-protein kinase MASK; Serine/threonine-protein kinase MST4; STE20-like kinase MST4; STK26
Gene Symbols: STK26
Molecular weight: 46,529 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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