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SPTAN1 a cytoskeletal protein which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Capable to forming dimers which can further associate to tetramers. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: cytosol; extracellular region; intracellular membrane-bound organelle; membrane; microtubule cytoskeleton; spectrin
Molecular Function: cadherin binding; protein binding; Ras guanyl-nucleotide exchange factor activity; structural constituent of cytoskeleton
Biological Process: axon guidance; ER to Golgi vesicle-mediated transport; MAPKKK cascade; neutrophil degranulation
Disease: Epileptic Encephalopathy, Early Infantile, 5
Reference #:  Q13813 (UniProtKB)
Alt. Names/Synonyms: (ALPHA)II-SPECTRIN; Alpha-II spectrin; FLJ44613; Fodrin alpha chain; NEAS; non-erythrocytic spectrin alpha; Spectrin alpha chain, brain; spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); Spectrin, non-erythroid alpha chain; SPTA2; SPTAN1
Gene Symbols: SPTAN1
Molecular weight: 284,539 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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