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TK cytosolic thymidine kinase. Phosphorylated during mitosis. Its enzymatic activity is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: cytosol
Molecular Function: identical protein binding; nucleoside kinase activity; protein binding; thymidine kinase activity; zinc ion binding
Biological Process: DNA metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; protein homotetramerization; pyrimidine nucleoside salvage; thymidine metabolic process
Reference #:  P04183 (UniProtKB)
Alt. Names/Synonyms: KITH; thymidine kinase 1 soluble isoform; thymidine kinase 1, soluble; Thymidine kinase, cytosolic; thymidine kinase-1; TK1; TK2
Gene Symbols: TK1
Molecular weight: 25,469 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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