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NDRG4 Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. Expressed predominantly in brain and heart. In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells. Belongs to the NDRG family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: basolateral plasma membrane; cytoplasm; endoplasmic reticulum membrane; mitochondrion
Molecular Function: protein binding
Biological Process: brain development; cardiac muscle cell proliferation; embryonic heart tube development; heart looping; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation
Reference #:  Q9ULP0 (UniProtKB)
Alt. Names/Synonyms: BDM1; Brain development-related molecule 1; DKFZp686I1615; FLJ30586; FLJ42011; KIAA1180; MGC19632; NDRG family member 4; NDRG4; Protein NDRG4; SMAP-8; smooth muscle-associated protein 8; Vascular smooth muscle cell-associated protein 8
Gene Symbols: NDRG4
Molecular weight: 38,459 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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