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TNC Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Belongs to the tenascin family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q33.1
Cellular Component: endoplasmic reticulum lumen; extracellular matrix; extracellular region; extracellular space; focal adhesion; membrane
Molecular Function: syndecan binding
Biological Process: cellular protein metabolic process; extracellular matrix organization and biogenesis; osteoblast differentiation; post-translational protein modification; response to wounding
Disease: Deafness, Autosomal Dominant 56
Reference #:  P24821 (UniProtKB)
Alt. Names/Synonyms: 150-225; Cytotactin; Glioma-associated-extracellular matrix antigen; GMEM; GP; GP 150-225; Hexabrachion; hexabrachion (tenascin); HXB; JI; MGC167029; Myotendinous antigen; Neuronectin; TENA; Tenascin; tenascin C; Tenascin-C; tenascin-C isoform 14/AD1/16; TN; TN-C; TNC
Gene Symbols: TNC
Molecular weight: 240,853 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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