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IL33 Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 19|19 C1
Cellular Component: cytosol; nucleoplasm; nucleus
Molecular Function: cytokine activity
Biological Process: defense response to virus; macrophage activation during immune response; microglial cell activation during immune response; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; negative regulation of leukocyte migration; negative regulation of T-helper 1 type immune response; positive regulation of immunoglobulin secretion; positive regulation of inflammatory response; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of interleukin-6 production; positive regulation of macrophage activation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T-helper 2 type immune response; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q8BVZ5 (UniProtKB)
Alt. Names/Synonyms: 9230117N10Rik; IL-33; Il1f11; Il33; interleukin 33; Interleukin-33; NF-HEV; nuclear factor from high endothelial venules
Gene Symbols: Il33
Molecular weight: 29,991 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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