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FOXP2 Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. 9 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding
Chromosomal Location of Human Ortholog: 7q31.1
Cellular Component: nucleus
Molecular Function: DNA binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity
Biological Process: anatomical structure morphogenesis; caudate nucleus development; cell differentiation; cerebral cortex development; negative regulation of transcription, DNA-dependent; putamen development
Disease: Speech-language Disorder 1
Reference #:  O15409 (UniProtKB)
Alt. Names/Synonyms: CAG repeat protein 44; CAGH44; DKFZp686H1726; forkhead box P2; Forkhead box protein P2; forkhead/winged-helix transcription factor; FOXP2; SPCH1; TNRC10; trinucleotide repeat containing 10; Trinucleotide repeat-containing gene 10 protein
Gene Symbols: FOXP2
Molecular weight: 79,919 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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