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DYNLL2 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Belongs to the dynein light chain family. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 17q22
Cellular Component: centrosome; cilium; cytoplasmic dynein complex; cytosol; membrane; myosin complex; nucleus; plasma membrane
Molecular Function: cytoskeletal protein binding; dynein intermediate chain binding; dynein light intermediate chain binding; plus-end-directed microtubule motor activity; protein binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; ER to Golgi vesicle-mediated transport; macroautophagy
Reference #:  Q96FJ2 (UniProtKB)
Alt. Names/Synonyms: 8 kDa dynein light chain b; DLC2; DLC8b; DNCL1B; DYL2; Dynein light chain 2, cytoplasmic; Dynein light chain LC8-type 2; dynein, light chain, LC8-type 2; DYNLL2; MGC17810; radial spoke 22 homolog; RSPH22
Gene Symbols: DYNLL2
Molecular weight: 10,350 Da
Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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