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DDC Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Homodimer. Belongs to the group II decarboxylase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - tyrosine; EC; Lyase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 7p12.2-p12.1
Cellular Component: cytosol
Molecular Function: aromatic-L-amino-acid decarboxylase activity; enzyme binding; protein binding
Biological Process: catecholamine biosynthetic process; indolalkylamine biosynthetic process
Disease: Aromatic L-amino Acid Decarboxylase Deficiency
Reference #:  P20711 (UniProtKB)
Alt. Names/Synonyms: AADC; Aromatic-L-amino-acid decarboxylase; DDC; DOPA decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase)
Gene Symbols: DDC
Molecular weight: 53,926 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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