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DBH Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tyrosine; Apoptosis; Cell cycle regulation; EC; Membrane protein, integral; Motility/polarity/chemotaxis; Oxidoreductase
Chromosomal Location of Human Ortholog: 9q34.2
Cellular Component: cytoplasm; extracellular space; intracellular membrane-bound organelle; membrane; secretory granule membrane
Molecular Function: catalytic activity; copper ion binding; dopamine beta-monooxygenase activity
Biological Process: catecholamine biosynthetic process; dopamine catabolic process; norepinephrine biosynthetic process; octopamine biosynthetic process; synaptic transmission
Disease: Dopamine Beta-hydroxylase Deficiency, Congenital
Reference #:  P09172 (UniProtKB)
Alt. Names/Synonyms: DBH; DBM; Dopamine beta-hydroxylase; dopamine beta-hydroxylase (dopamine beta-monooxygenase); Dopamine beta-monooxygenase; DOPO; Soluble dopamine beta-hydroxylase
Gene Symbols: DBH
Molecular weight: 69,065 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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