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HSL hormone sensitive lipase is a lipolytic enzyme of the 'GDXG' family. Plays a rate limiting step in triglyceride lipolysis. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin. Note: This description may include information from UniProtKB.
Protein type: EC; Lipase
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: cytosol; lipid particle
Molecular Function: protein binding
Biological Process: lipid catabolic process; protein amino acid phosphorylation
Disease: Abdominal Obesity-metabolic Syndrome 4
Reference #:  Q05469 (UniProtKB)
Alt. Names/Synonyms: Hormone-sensitive lipase; hormone-sensitive lipase testicular isoform; HSL; LHS; lipase, hormone-sensitive; LIPE; LIPS
Gene Symbols: LIPE
Molecular weight: 116,598 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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