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GMCSF Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11 B1.3|11 32.13 cM
Cellular Component: extracellular space; intracellular membrane-bound organelle
Molecular Function: cytokine activity
Biological Process: embryonic placenta development; epithelial fluid transport; histamine secretion; macrophage activation; monocyte differentiation; myeloid dendritic cell differentiation; negative regulation of cytolysis; neutrophil differentiation; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of interleukin-23 production; positive regulation of tyrosine phosphorylation of STAT protein; regulation of cell proliferation; regulation of circadian sleep/wake cycle, sleep; regulation of gene expression
Reference #:  P01587 (UniProtKB)
Alt. Names/Synonyms: colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; Csf2; Csfgm; GM-CSF; granulocyte-macrophage colony stimulating factor 2; Granulocyte-macrophage colony-stimulating factor; MGC151255; MGC151257; MGI-IGM; OTTMUSP00000005830; put. GM-CSF
Gene Symbols: Csf2
Molecular weight: 16,091 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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