CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell surface; Membrane protein, integral
Cellular Component: anchored to plasma membrane; cell surface; cytoplasmic side of plasma membrane; external side of plasma membrane; extracellular region; integral component of plasma membrane; intercellular junction; plasma membrane
Molecular Function: protein binding; protein homodimerization activity; receptor activity; receptor binding
Biological Process: apoptosis; cell surface receptor signaling pathway; heterotypic cell-cell adhesion; leukocyte migration; lipid raft polarization; natural killer cell activation; positive regulation of myeloid dendritic cell activation; positive regulation of tumor necrosis factor production; regulation of T cell differentiation; T cell activation