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CD2 CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p13.1
Cellular Component: anchored to plasma membrane; cell surface; cytoplasmic side of plasma membrane; external side of plasma membrane; extracellular region; integral component of plasma membrane; intercellular junction; plasma membrane
Molecular Function: protein binding; protein homodimerization activity; receptor activity; receptor binding
Biological Process: apoptosis; cell surface receptor signaling pathway; heterotypic cell-cell adhesion; leukocyte migration; lipid raft polarization; natural killer cell activation; positive regulation of myeloid dendritic cell activation; positive regulation of tumor necrosis factor production; regulation of T cell differentiation; T cell activation
Reference #:  P06729 (UniProtKB)
Alt. Names/Synonyms: CD2; CD2 antigen (p50), sheep red blood cell receptor; CD2 molecule; Erythrocyte receptor; FLJ46032; LFA-2; LFA-3 receptor; lymphocyte-function antigen-2; Rosette receptor; SRBC; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5; T11
Gene Symbols: CD2
Molecular weight: 39,448 Da
Basal Isoelectric point: 9.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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