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PAX8 Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Interacts with WWTR1. Expressed in the excretory system, thyroid gland and Wilms tumors. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 2q14.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding; thyroid-stimulating hormone receptor activity; transcription factor activity
Biological Process: anatomical structure morphogenesis; central nervous system development; inner ear morphogenesis; kidney development; mesonephros development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; pronephros development; regulation of apoptosis; thyroid gland development; transcription, DNA-dependent; ureteric bud branching; urogenital system development
Disease: Hypothyroidism, Congenital, Nongoitrous, 2
Reference #:  Q06710 (UniProtKB)
Alt. Names/Synonyms: paired box 8; Paired box protein Pax-8; paired domain gene 8; PAX8
Gene Symbols: PAX8
Molecular weight: 48,218 Da
Basal Isoelectric point: 7.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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