Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

FOXP1 Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 3p13
Cellular Component: nucleoplasm; nucleus
Molecular Function: androgen receptor binding; protein binding; protein self-association
Biological Process: endothelial cell activation; macrophage activation; monocyte activation; negative regulation of B cell apoptosis; negative regulation of transcription, DNA-dependent; osteoclast differentiation; positive regulation of smooth muscle cell proliferation; regulation of inflammatory response; regulation of interleukin-1 beta secretion; regulation of monocyte differentiation; regulation of tumor necrosis factor production; response to lipopolysaccharide; somatic stem cell maintenance
Disease: Mental Retardation With Language Impairment And With Or Without Autistic Features
Reference #:  Q9H334 (UniProtKB)
Alt. Names/Synonyms: 12CC4; FLJ23741; fork head-related protein like B; forkhead box P1; Forkhead box protein P1; FOXP1; glutamine-rich factor 1; hFKH1B; HSPC215; MGC12942; MGC88572; MGC99551; QRF1
Gene Symbols: FOXP1
Molecular weight: 75,317 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein