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BMP7 Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20q13.31
Cellular Component: extracellular region; extracellular space
Molecular Function: cytokine activity; protein binding; transforming growth factor beta receptor binding
Biological Process: BMP signaling pathway; cardiac muscle development; dendrite development; epithelial to mesenchymal transition; hindbrain development; inhibition of NF-kappaB transcription factor; mesenchymal cell differentiation; mesonephros development; metanephros development; negative regulation of cell cycle; negative regulation of MAP kinase activity; negative regulation of mitosis; negative regulation of neuron differentiation; negative regulation of NF-kappaB import into nucleus; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; neural fold elevation formation; neurite morphogenesis; pharyngeal system development; positive regulation of bone mineralization; positive regulation of heterotypic cell-cell adhesion; positive regulation of osteoblast differentiation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; skeletal development; steroid hormone mediated signaling; ureteric bud development
Reference #:  P18075 (UniProtKB)
Alt. Names/Synonyms: BMP-7; BMP7; Bone morphogenetic protein 7; OP-1; OP1; Osteogenic protein 1
Gene Symbols: BMP7
Molecular weight: 49,313 Da
Basal Isoelectric point: 7.74  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Wnt/ß-Catenin Signaling
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