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Oct7 Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters. Interacts with PQBP1. Expressed specifically in the neuroectodermal cell lineage. Belongs to the POU transcription factor family. Class- 3 subfamily. 3 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 6q16.1
Cellular Component: nucleus
Molecular Function: identical protein binding; protein binding; transcription factor activity
Biological Process: nervous system development; neuron development; neuron differentiation; neuron fate commitment; neuron fate specification; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter
Reference #:  P20265 (UniProtKB)
Alt. Names/Synonyms: Brain-2; Brain-specific homeobox/POU domain protein 2; Brn-2; BRN2; Nervous system-specific octamer-binding transcription factor N-Oct-3; Oct-7; OCT7; Octamer-binding protein 7; Octamer-binding transcription factor 7; OTF-7; OTF7; PO3F2; POU class 3 homeobox 2; POU domain, class 3, transcription factor 2; POU3F2; POUF3
Gene Symbols: POU3F2
Molecular weight: 46,893 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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