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PAK2 a protein kinase of the STE20 family. Critical effector linking RhoGTPases to cytoskeleton reorganization and nuclear signaling. Activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; PAKA subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 16 B2|16 22.4 cM
Cellular Component: cytoplasm; cytosol
Molecular Function: cadherin binding; identical protein binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activator activity; Rac GTPase binding; small GTPase binding
Biological Process: actin cytoskeleton organization and biogenesis; activation of protein kinase activity; cell migration; negative regulation of apoptosis; peptidyl-serine phosphorylation; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of MAPKKK cascade; regulation of mitotic cell cycle; Rho protein signal transduction; stress-activated protein kinase signaling pathway
Reference #:  Q8CIN4 (UniProtKB)
Alt. Names/Synonyms: A130002K10Rik; AI836325; D16Ertd269e; Gamma-PAK; KIAA4182; mKIAA4182; OTTMUSP00000028355; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; PAK-2; PAK-2p27; PAK-2p34; Pak2; Serine/threonine-protein kinase PAK 2
Gene Symbols: Pak2
Molecular weight: 57,930 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Microtubule Dynamics  |  TGF-ß Signaling
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