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TUBG1 Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta tubulin minus-end nucleation, centrosome duplication and spindle formation. Interacts with GCP2 and GCP3. Interacts with B9D2. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO/C1orf88. Belongs to the tubulin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: centrosome; condensed nuclear chromosome; cytoplasm; cytosol; gamma-tubulin complex; polar microtubule; recycling endosome
Molecular Function: protein binding; structural constituent of cytoskeleton
Biological Process: G2/M transition of mitotic cell cycle; meiotic spindle organization and biogenesis; microtubule cytoskeleton organization and biogenesis
Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 4
Reference #:  P23258 (UniProtKB)
Alt. Names/Synonyms: Gamma-1-tubulin; Gamma-tubulin complex component 1; GCP-1; TBG1; TUBG; TUBG1; TUBGCP1; Tubulin gamma-1 chain; tubulin, gamma 1; tubulin, gamma polypeptide
Gene Symbols: TUBG1
Molecular weight: 51,170 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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