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APR3 May play a critical role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. Up-regulated by all-trans-retinoic acid (ATRA) in several tumor cell lines. Weakly expressed in hematopoietic cell lines. 3 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: nuclear envelope; perinuclear region of cytoplasm
Molecular Function: protein binding
Biological Process: negative regulation of osteoblast proliferation; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; regulation of gene expression
Reference #:  Q6UW56 (UniProtKB)
Alt. Names/Synonyms: apoptosis related protein 3; apoptosis related protein APR-3; Apoptosis-related protein 3; APR--3; APR-3; APR3; C2orf28; chromosome 2 open reading frame 28; HSPC013; p18; PRO240
Gene Symbols: ATRAID
Molecular weight: 24,747 Da
Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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