an atypical protein kinase that functions as a transcriptional repressor. Translocation with RET generates the TRIM33/RET (PTC7) oncogene. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Molecular Function: co-SMAD binding; DNA binding; protein binding; R-SMAD binding; ubiquitin-protein transferase activity; zinc ion binding
Biological Process: negative regulation of BMP signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein ubiquitination; regulation of transforming growth factor beta receptor signaling pathway; transcription, DNA-dependent