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WIPI2 Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P. Interacts with TECPR1. Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. Belongs to the WD repeat SVP1 family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy
Chromosomal Location of Human Ortholog: 7p22.1
Cellular Component: autophagic vacuole; cytosol; extrinsic to membrane; membrane; pre-autophagosomal structure membrane; protein complex
Molecular Function: phosphatidylinositol 3-phosphate binding; protein binding
Biological Process: autophagic vacuole formation; macroautophagy; mitochondrion degradation; protein amino acid lipidation
Reference #:  Q9Y4P8 (UniProtKB)
Alt. Names/Synonyms: Atg21; CGI-50; DKFZp434J154; DKFZp686P02188; FLJ12979; FLJ14217; FLJ42984; WD repeat domain phosphoinositide-interacting protein 2; WD repeat domain, phosphoinositide interacting 2; WD40 repeat protein interacting with phosphoinositides 2; WIPI-2; WIPI2; WIPI49-like protein 2
Gene Symbols: WIPI2
Molecular weight: 49,408 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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