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ACTA2 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family. Note: This description may include information from UniProtKB.
Protein type: Contractile; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q23.31
Cellular Component: cytoplasm; cytosol; extracellular space; filopodium; lamellipodium; protein complex
Molecular Function: protein kinase binding
Biological Process: muscle contraction; response to virus
Disease: Aortic Aneurysm, Familial Thoracic 6; Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome
Reference #:  P62736 (UniProtKB)
Alt. Names/Synonyms: AAT6; ACTA; ACTA2; actin, alpha 2, smooth muscle, aorta; Actin, aortic smooth muscle; ACTSA; ACTVS; alpha 2 actin; Alpha-actin-2; alpha-cardiac actin; Cell growth-inhibiting gene 46 protein; growth-inhibiting gene 46
Gene Symbols: ACTA2
Molecular weight: 42,009 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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