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SETD7 Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Interacts with IPF1/PDX-1. Widely expressed. Expressed in pancreatic islets. Belongs to the histone-lysine methyltransferase family. SET7 subfamily. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; EC; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of Human Ortholog: 4q31.1
Cellular Component: nucleolus; nucleoplasm
Molecular Function: histone-lysine N-methyltransferase activity; p53 binding; protein binding; protein-lysine N-methyltransferase activity
Biological Process: peptidyl-lysine di-methylation; peptidyl-lysine mono-methylation; response to DNA damage stimulus
Reference #:  Q8WTS6 (UniProtKB)
Alt. Names/Synonyms: FLJ21193; H3-K4-HMTase SETD7; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; Histone-lysine N-methyltransferase SETD7; KIAA1717; KMT7; Lysine N-methyltransferase 7; SET domain containing (lysine methyltransferase) 7; SET domain-containing protein 7; SET7; SET7/9; SET9; SETD7
Gene Symbols: SETD7
Molecular weight: 40,721 Da
Basal Isoelectric point: 4.5  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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