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RABGEF1 Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. Interacts with RGS14; the interaction is GTP-dependent. Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAP, Rab; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q11.21
Cellular Component: cytosol; early endosome; early endosome membrane; nucleolus
Molecular Function: protein binding; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity
Biological Process: protein targeting to membrane
Reference #:  Q9UJ41 (UniProtKB)
Alt. Names/Synonyms: FLJ32302; RAB guanine nucleotide exchange factor (GEF) 1; Rab5 GDP/GTP exchange factor; Rabaptin-5-associated exchange factor for Rab5; Rabex-5; RABEX5; RABGEF1; RABX5; RAP1
Gene Symbols: RABGEF1
Molecular weight: 79,371 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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