Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

MUTYH Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities. Belongs to the Nth/MutY family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC 3.2.2.-; Hydrolase; Mitochondrial; Tumor suppressor
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA N-glycosylase activity; MutLalpha complex binding; MutLbeta complex binding; MutSalpha complex binding; MutSbeta complex binding; protein binding; purine-specific mismatch base pair DNA N-glycosylase activity
Biological Process: depurination; DNA repair; mismatch repair
Disease: Familial Adenomatous Polyposis, 2; Gastric Cancer; Pilomatrixoma
Reference #:  Q9UIF7 (UniProtKB)
Alt. Names/Synonyms: A/G-specific adenine DNA glycosylase; CYP2C; hMYH; MGC4416; MutY homolog; mutY homolog (E. coli); MUTYH; MYH
Gene Symbols: MUTYH
Molecular weight: 60,069 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein