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Protein Page:

CREB3L3 Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Belongs to the bZIP family. ATF subfamily. Binds DNA as a dimer. Probably homodimerizes. Probably forms a heterodimer with ATF6. Interacts with ATF6. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transcription factor
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; membrane; nucleoplasm; nucleus
Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: positive regulation of transcription from RNA polymerase II promoter; unfolded protein response
Reference #:  Q68CJ9 (UniProtKB)
Alt. Names/Synonyms: cAMP responsive element binding protein 3-like 3; cAMP-responsive element-binding protein 3-like protein 3; CR3L3; CREB-H; CREB/ATF family transcription factor; CREB3L3; CREBH; Cyclic AMP-responsive element-binding protein 3-like protein 3; HYST1481; MGC126553; MGC126557; Processed cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H
Gene Symbols: CREB3L3
Molecular weight: 49,077 Da
Basal Isoelectric point: 4.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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