Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Belongs to the bZIP family. ATF subfamily. Binds DNA as a dimer. Probably homodimerizes. Probably forms a heterodimer with ATF6. Interacts with ATF6. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transcription factor
Alt. Names/Synonyms: cAMP responsive element binding protein 3-like 3; cAMP-responsive element-binding protein 3-like protein 3; CR3L3; CREB-H; CREB/ATF family transcription factor; CREB3L3; CREBH; Cyclic AMP-responsive element-binding protein 3-like protein 3; HYST1481; MGC126553; MGC126557; Processed cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H