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Protein Page:
CD8A

Overview
CD8A Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6 C1|6 32.14 cM
Cellular Component: cell surface; external side of plasma membrane; integral component of membrane; membrane
Molecular Function: protein binding; protein homodimerization activity; protein kinase binding
Biological Process: adaptive immune response; cell surface receptor signaling pathway; cytotoxic T cell differentiation; defense response to virus; immune system process; positive regulation of calcium-mediated signaling; T cell activation; T cell mediated immunity
Reference #:  P01731 (UniProtKB)
Alt. Names/Synonyms: BB154331; CD8 antigen, alpha chain; Cd8a; Ly-2; Ly-35; Ly-B; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); Lyt2; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2
Gene Symbols: Cd8a
Molecular weight: 27,456 Da
Basal Isoelectric point: 9.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CD8A

Protein Structure Not Found.
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