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BCAT2 Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. Homodimer. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC; Mitochondrial; Transferase
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: mitochondrial matrix; mitochondrion
Molecular Function: branched-chain-amino-acid transaminase activity
Biological Process: branched chain family amino acid biosynthetic process; branched chain family amino acid catabolic process; leucine biosynthetic process; valine biosynthetic process
Reference #:  O15382 (UniProtKB)
Alt. Names/Synonyms: BCAM; BCAT(m); BCAT2; BCATM; BCT2; branched chain aminotransferase 2, mitochondrial; branched-chain amino acid aminotransferase; Branched-chain-amino-acid aminotransferase, mitochondrial; ECA40; Placental protein 18; PP18
Gene Symbols: BCAT2
Molecular weight: 44,288 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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