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BCAP31 May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis. Homodimer and heterodimer with BCAP29. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB. Ubiquitous. Belongs to the BCAP29/BCAP31 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: X|X A7.3
Cellular Component: clathrin-coated vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; integral to plasma membrane; lipid particle; membrane; plasma membrane; translocon complex
Molecular Function: MHC class I protein binding; protein binding; protein complex binding
Biological Process: elevation of cytosolic calcium ion concentration; elevation of mitochondrial calcium ion concentration; ER to Golgi vesicle-mediated transport; immune response; positive regulation of caspase activity; reduction of endoplasmic reticulum calcium ion concentration; spermatogenesis
Reference #:  Q61335 (UniProtKB)
Alt. Names/Synonyms: accessory protein BAP31; B-cell receptor-associated protein 31; Bap31; Bcap31; BCR-associated protein 31; OTTMUSP00000019276; p28
Gene Symbols: Bcap31
Molecular weight: 27,957 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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