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A6 Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down- regulated. Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver. Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: actin cytoskeleton; cytosol; filopodium; focal adhesion; intercellular junction; myofibril; perinuclear region of cytoplasm
Molecular Function: actin monomer binding; ATP binding; cadherin binding; phosphatidylinositol-4,5-bisphosphate binding; protein-tyrosine kinase activity
Biological Process: negative regulation of actin filament polymerization; regulation of actin phosphorylation; sequestering of actin monomers
Reference #:  Q12792 (UniProtKB)
Alt. Names/Synonyms: A6; A6 protein tyrosine kinase; MGC23788; MGC41876; Protein A6; Protein tyrosine kinase 9; PTK9; PTK9 protein tyrosine kinase 9; TWF1; twinfilin, actin-binding protein, homolog 1 (Drosophila); Twinfilin-1
Gene Symbols: TWF1
Molecular weight: 40,283 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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