Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons. Interacts with RUFY3. Belongs to the shootin family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: axon; cytoplasm; filopodium; growth cone; lamellipodium; leading edge; microtubule associated complex; microtubule cytoskeleton; perikaryon; perinuclear region of cytoplasm
Molecular Function: actin filament binding; cadherin binding; protein binding
Biological Process: axonogenesis; Cdc42 protein signal transduction; neurite morphogenesis; positive regulation of axon extension; Ras protein signal transduction; substrate-bound cell migration, cell extension