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CARD9 Activates NF-kappa-B via BCL10. Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2). Chronic mucocutaneous candidiasis is characterized by impaired clearance of fungal infections and results in colonization and infections of the mucosa or skin, predominantly with Candida albicans. CANDF2 is an autosomal recessive chronic mucocutaneous candidiasis. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: cytoplasm; cytosol; plasma membrane
Molecular Function: CARD domain binding; protein binding; protein homodimerization activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of stress-activated MAPK cascade; stimulatory C-type lectin receptor signaling pathway
Disease: Candidiasis, Familial, 2
Reference #:  Q9H257 (UniProtKB)
Alt. Names/Synonyms: CARD9; caspase recruitment domain family, member 9; Caspase recruitment domain-containing protein 9; hCARD9
Gene Symbols: CARD9
Molecular weight: 62,241 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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