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NSAP1 a heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. A component of the spliceosome. Five alternatively spliced isoforms have been described. Isoform 1, 2 and 3 are associated with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to ACF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 6q14.3
Cellular Component: membrane; nucleus; ribonucleoprotein complex
Molecular Function: protein binding; RNA binding
Biological Process: negative regulation of translation; nuclear mRNA splicing, via spliceosome; osteoblast differentiation; RNA processing; RNA splicing
Reference #:  O60506 (UniProtKB)
Alt. Names/Synonyms: dJ3J17.2; FLJ31626; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; GRYRBP; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; hnRNP-Q; HNRPQ; HNRPQ1; NS1-associated protein 1; NSAP1; PP68; synaptotagmin binding, cytoplasmic RNA interacting protein; Synaptotagmin-binding, cytoplasmic RNA-interacting protein; SYNCRIP
Gene Symbols: SYNCRIP
Molecular weight: 69,603 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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