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SENP1 Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Nuclear receptor co-regulator; Protease
Chromosomal Location of Human Ortholog: 12q13.11
Cellular Component: focal adhesion; nuclear membrane; nucleoplasm; nucleus
Molecular Function: endopeptidase activity; protein binding; SUMO-specific protease activity
Biological Process: caspase activation; positive regulation of transcription from RNA polymerase II promoter; protein desumoylation; protein sumoylation; proteolysis
Reference #:  Q9P0U3 (UniProtKB)
Alt. Names/Synonyms: SENP1; Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SUMO1/sentrin specific peptidase 1; SUMO1/sentrin specific protease 1; SuPr-2
Gene Symbols: SENP1
Molecular weight: 73,481 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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