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Protein Page:

TOP2A a DNA topoisomerase. Controls of topological states of DNA by transient breakage and rejoining of DNA. Makes double-strand breaks. Four splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Isomerase
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: centriole; DNA topoisomerase complex (ATP-hydrolyzing); nuclear chromosome; nucleolus; nucleoplasm; nucleus; protein complex
Molecular Function: chromatin binding; DNA bending activity; DNA binding; DNA topoisomerase (ATP-hydrolyzing) activity; DNA-dependent ATPase activity; drug binding; enzyme binding; histone deacetylase binding; magnesium ion binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; protein kinase C binding; RNA binding; ubiquitin binding
Biological Process: apoptotic chromosome condensation; chromosome segregation; DNA ligation; DNA topological change; positive regulation of apoptosis; positive regulation of retroviral genome replication; positive regulation of viral genome replication; protein sumoylation; regulation of circadian rhythm; resolution of meiotic joint molecules as recombinants; response to DNA damage stimulus; sister chromatid segregation
Reference #:  P11388 (UniProtKB)
Alt. Names/Synonyms: DNA topoisomerase 2-alpha; DNA topoisomerase II, 170 kD; DNA topoisomerase II, alpha isozyme; TOP2; TOP2A; topoisomerase (DNA) II alpha 170kDa; TP2A
Gene Symbols: TOP2A
Molecular weight: 174,385 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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