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TLR6 Participates in the innate immune response to Gram- positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. Belongs to the Toll-like receptor family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 4p14
Cellular Component: Golgi apparatus; integral to plasma membrane; intracellular; lipid raft; plasma membrane; receptor complex
Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; receptor activity; receptor binding; transmembrane receptor activity
Biological Process: activation of NF-kappaB transcription factor; cell activation; defense response to bacterium; detection of diacylated bacterial lipoprotein; immune response; interleukin-1 beta secretion; leukocyte activation during inflammatory response; MyD88-dependent toll-like receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK activity; positive regulation of nitric oxide biosynthetic process; signal transduction; T-helper 1 type immune response; toll-like receptor signaling pathway
Reference #:  Q9Y2C9 (UniProtKB)
Alt. Names/Synonyms: CD286; TLR6; Toll-like receptor 6
Gene Symbols: TLR6
Molecular weight: 91,880 Da
Basal Isoelectric point: 6.83  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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