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PECAM-1 a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component: cell junction; extracellular exosome; extracellular space; integral component of membrane; membrane raft; plasma membrane; platelet alpha granule membrane; secretory granule membrane
Molecular Function: protein binding; protein homodimerization activity
Biological Process: cell recognition; cell-cell adhesion via plasma-membrane adhesion molecules; diapedesis; extracellular matrix organization; glomerular endothelium development; homophilic cell adhesion; leukocyte adhesion; leukocyte migration; neutrophil degranulation; neutrophil extravasation; phagocytosis; platelet degranulation; signal transduction
Reference #:  P16284 (UniProtKB)
Alt. Names/Synonyms: adhesion molecule; CD31; CD31 antigen; CD31/EndoCAM; EndoCAM; FLJ58394; GPIIA'; PECA1; PECAM-1; PECAM-1, CD31/EndoCAM; PECAM1; Platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule
Gene Symbols: PECAM1
Molecular weight: 82,536 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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