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DDX4 May play a role in germ cell development. May play a role in sperm motility. Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. N-terminus interacts with RANBP9. Interacts with PIWIL2 and MAEL. Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component: cytoplasm; nucleolus; perinuclear region of cytoplasm
Molecular Function: ATP-dependent RNA helicase activity
Biological Process: DNA methylation during gametogenesis; male meiosis; RNA secondary structure unwinding; sperm motility; spermatogenesis
Reference #:  Q9NQI0 (UniProtKB)
Alt. Names/Synonyms: DDX4; DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; DEAD box protein 4; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4; MGC111074; Probable ATP-dependent RNA helicase DDX4; VASA; Vasa homolog
Gene Symbols: DDX4
Molecular weight: 79,308 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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