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IGFBP2 Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Binds IGF2 more than IGF1. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: extracellular region; extracellular space
Molecular Function: insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding; receptor binding
Biological Process: cellular protein metabolic process; positive regulation of activated T cell proliferation; regulation of insulin-like growth factor receptor signaling pathway
Reference #:  P18065 (UniProtKB)
Alt. Names/Synonyms: BP2; IBP-2; IBP2; IGF-binding protein 2; IGF-BP53; IGFBP-2; IGFBP2; insulin-like growth factor binding protein 2, 36kDa; Insulin-like growth factor-binding protein 2
Gene Symbols: IGFBP2
Molecular weight: 34,814 Da
Basal Isoelectric point: 7.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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