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EVI1 a zinc finger transcriptional regulator that binds to DNA sequences in the promoter region of target genes and positively or negatively regulates their expression. An oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Originally identified as a common site of viral integration in murine myeloid leukemia. Involved in human myeloid disorders through chromosome translocation and inversion and is also implicated in solid tumor formation. At least six isoforms of the human protein are formed due to alternative usage of 5'-ends, alternative splicing, and intergenic splicing which results in the formation of a fusion protein with MDS1, which can be expressed in normal tissues. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 3q26.2
Cellular Component: cytosol; histone deacetylase complex; nuclear speck; nucleus
Molecular Function: DNA binding; histone-lysine N-methyltransferase activity; protein binding; transcription factor activity
Biological Process: negative regulation of JNK cascade; negative regulation of programmed cell death; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of cell cycle
Reference #:  Q03112 (UniProtKB)
Alt. Names/Synonyms: AML1-EVI-1 fusion partner; ecotropic viral integration site 1; Ecotropic virus integration site 1 protein homolog; EVI-1; EVI1; MDS1; MDS1 and EVI1 complex locus; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; MDS1-EVI1; MECOM; MGC163392; MGC97004; myelodysplasia syndrome 1 protein; myelodysplasia syndrome-associated protein 1; oncogene EVI1; PRDM3; zinc finger protein Evi1
Gene Symbols: MECOM
Molecular weight: 118,276 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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