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PANK2 a pantothenate kinase that catalyzes the first committed step in the biosynthesis of coenzyme A, an essential cofactor in cellular metabolism. PANK2 is predominantly localized in mitochondria in primates. Defects in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Three isoforms of the human PANK2, produced by alternative splicing, have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC; Kinase, other; Mitochondrial
Chromosomal Location of Human Ortholog: 2|2 F1
Cellular Component: cytosol; mitochondrion
Molecular Function: pantothenate kinase activity
Biological Process: aerobic respiration; coenzyme A biosynthetic process; regulation of fatty acid metabolic process; regulation of mitochondrial membrane potential; spermatid development
Reference #:  Q7M753 (UniProtKB)
Alt. Names/Synonyms: 4933409I19Rik; AI642621; MGC118448; OTTMUSP00000017161; Pank2; Pantothenate kinase 2; pantothenate kinase 2 (Hallervorden-Spatz syndrome)
Gene Symbols: Pank2
Molecular weight: 50,212 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
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