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PRAS40 plays a role in phosphatidylinositol 3-kinase (PI3K)/AKT survival signaling. PRAS40 is a physiological target of in vivo insulin action. Hyperinsulinemia increased its phosphorylation in human skeletal muscle biopsies. Phosphorylated PRAS40 is predominantly localized to the nucleus. In rats fed a high-fat diet (HFD), phosphorylation of PRAS40 was markedly reduced when compared with low-fat diet-fed animals in all tissues examined. A novel mTOR binding partner that mediates Akt signals to mTOR. Binding of PRAS40 inhibits mTOR activity and suppresses constitutive activation of mTOR in cells lacking TSC2. Phosphorylation by Akt and perhaps related kinases leads to its binding to 14-3-3. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: protein binding
Biological Process: negative regulation of cell size; negative regulation of protein kinase activity; negative regulation of TOR signaling pathway; regulation of apoptosis; regulation of neuron apoptosis
Reference #:  Q96B36 (UniProtKB)
Alt. Names/Synonyms: AKT1S1; proline-rich AKT1 substrate 1
Gene Symbols: AKT1S1
Molecular weight: 27,383 Da
Basal Isoelectric point: 4.65  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  T Cell Receptor Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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