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STXBP1 may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm; plasma membrane; protein complex
Molecular Function: identical protein binding; protein binding; RNA binding; SNARE binding; syntaxin binding; syntaxin-1 binding
Biological Process: axon target recognition; glutamate secretion; negative regulation of synaptic transmission, GABAergic; neurotransmitter secretion; platelet degranulation; regulation of synaptic vesicle fusion to presynaptic membrane; synaptic vesicle maturation; vesicle docking during exocytosis
Disease: Epileptic Encephalopathy, Early Infantile, 4
Reference #:  P61764 (UniProtKB)
Alt. Names/Synonyms: FLJ37475; MUNC18-1; N-Sec1; neuronal SEC1; NSEC1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; RBSEC1; STXB1; STXBP1; syntaxin binding protein 1; Syntaxin-binding protein 1; Unc-18A; UNC18; Unc18-1; UNC18A
Gene Symbols: STXBP1
Molecular weight: 67,569 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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