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DR6 May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Associates with TRADD. Interacts with N-APP. Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 6p12.3
Cellular Component: integral to plasma membrane; intrinsic to plasma membrane; plasma membrane
Molecular Function: protein binding; tumor necrosis factor receptor activity
Biological Process: adaptive immune response; apoptosis; B cell apoptosis; humoral immune response; immune response; inflammatory response; myelination; negative regulation of B cell proliferation; negative regulation of myelination; negative regulation of T cell proliferation; neuron apoptosis; regulation of apoptosis; regulation of cell proliferation; regulation of lipid metabolic process; regulation of oligodendrocyte differentiation; response to lipopolysaccharide; T cell receptor signaling pathway
Reference #:  O75509 (UniProtKB)
Alt. Names/Synonyms: BM-018; Death receptor 6; DR6; MGC31965; TNFR-related death receptor 6; TNFRSF21; TNR21; Tumor necrosis factor receptor superfamily member 21; tumor necrosis factor receptor superfamily, member 21
Gene Symbols: TNFRSF21
Molecular weight: 71,845 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
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