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CD14 Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 18 B2|18 19.46 cM
Cellular Component: anchored component of external side of plasma membrane; cell surface; external side of plasma membrane; extracellular region; extracellular space; Golgi apparatus; lipopolysaccharide receptor complex; membrane; membrane raft; plasma membrane
Molecular Function: lipopolysaccharide binding
Biological Process: immune system process; inflammatory response; innate immune response; lipopolysaccharide-mediated signaling pathway; positive regulation of cytokine secretion; positive regulation of endocytosis; positive regulation of interferon type I production; positive regulation of interferon-gamma production; positive regulation of tumor necrosis factor production; receptor-mediated endocytosis; response to bacterium; response to molecule of bacterial origin; toll-like receptor 4 signaling pathway
Reference #:  P10810 (UniProtKB)
Alt. Names/Synonyms: Cd14; CD14 antigen; Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein
Gene Symbols: Cd14
Molecular weight: 39,204 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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