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HOMER1 Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell development/differentiation
Chromosomal Location of Human Ortholog: 5q14.1
Cellular Component: cytosol
Molecular Function: metabotropic glutatmate receptor binding; protein binding
Biological Process: metabotropic glutamate receptor, phospholipase C activating pathway; positive regulation of signal transduction; response to calcium ion; synaptic transmission
Reference #:  Q86YM7 (UniProtKB)
Alt. Names/Synonyms: HOME1; HOMER; homer homolog 1 (Drosophila); Homer protein homolog 1; homer, neuronal immediate early gene, 1; Homer-1; HOMER1; HOMER1A; HOMER1B; HOMER1C; SYN47; Ves-1
Gene Symbols: HOMER1
Molecular weight: 40,277 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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