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RECQL4 DNA-dependent ATPase. May modulate chromosome segregation. Interacts with UBR1 and UBR2. Interacts with MCM10; this interaction regulates RECQL4 unwinding activity. Up-regulated in actively dividing cells. Ubiquitously expressed, with highest levels in thymus and testis. Belongs to the helicase family. RecQ subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: chromosome, telomeric region; cytoplasm; membrane; nucleus
Molecular Function: ATP binding; ATP-dependent 3'-5' DNA helicase activity; bubble DNA binding; four-way junction helicase activity; helicase activity; oxidized purine DNA binding; protein binding
Biological Process: base-excision repair; DNA duplex unwinding; DNA repair; DNA replication; DNA strand renaturation; double-strand break repair via homologous recombination; multicellular organismal development; telomere maintenance
Disease: Baller-gerold Syndrome; Rapadilino Syndrome; Rothmund-thomson Syndrome
Reference #:  O94761 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent DNA helicase Q4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; RECQ4; RECQL4; RTS
Gene Symbols: RECQL4
Molecular weight: 133,077 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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